Van de Ven Brace Halts Everton's Run at New Home Ground
The Dutch defender emerged as the first defender to score two goals in a Premier League match for Tottenham since the Belgian defender in spring 2013.
Match summary
Micky Van de Ven nods into the net twice in opening period
The home side's defender has goal ruled after video check
Pape Matar Sarr scores third in dying moments
The defeat is Everton's first at Hill Dickinson Stadium
Micky van de Ven found the net on two occasions as Spurs prolonged their winning streak in away games in the top division and delivered Everton their first defeat at their new home.
The Toffees were undefeated in their last five matches at their recently opened stadium at Bramley-Moore Dock, having left their historic home behind after more than a century at the conclusion of last season.
But Tottenham's leader the Dutchman pounced on two occasions from set-pieces in the opening 45 minutes to put their impressive record at jeopardy, and they were failed to mount a comeback before Pape Matar Sarr - set up by former Toffees attacker the Brazilian - nodded in a final goal to seal the victory.
Jake O'Brien thought he had equalized the scores a short while after Van de Ven's first goal, glancing a bullet header past the Spurs keeper from an Everton corner.
Beto, meanwhile, failed to convert a handful of opportunities, while Vicario made a series of excellent saves to ensure the London club went five away games unbeaten in the English top flight.
But the video assistant referee stepped in, advising the match official to review the goal on the pitchside monitor and the official decided that Jack Grealish and Iliman Ndiaye were in an illegal position and had impeded with the Tottenham goalkeeper.
This victory elevates Thomas Frank's side up to third in the division, a handful of points off local foes and leaders Arsenal.
Everton stay 14th and sit six points ahead of the relegation zone.
Spurs breakdown: Van de Ven fulfils role at both ends of pitch
After a uninspiring weekday performance in the European competition against Monaco, where they managed a mere two shots on target, Frank opted for the French striker in attack instead of former Toffees player the Brazilian.
The summer signing was unable to influence the game before being replaced for Richarlison after 60 minutes on the pitch, but it turns out he wasn't needed in the final outcome.
Centre-back Van de Ven converted into an attacking force to be feared.
Tottenham's first goal came from a well-worked corner routine, with the midfielder directing the ball back across the face of goal for an unmarked the defender to head home.
And Ven de Ven - stepping up as skipper in Cristian Romero's absence - added his second in added time as he rose above the England keeper to nod in.
Van de Ven was equally outstanding in defensive duties, combining well with Kevin Danso as the pair dealt superbly with the numerous deliveries sent their way by Everton.
Everton analysis: Everton missing striker's instinct
The club's recent stadium had been a fortress, but it seems the freshness may have faded somewhat and supporters flocked to the gates after Sarr's final goal for Spurs.
The end in Everton's unbeaten home run will not be a massive worry for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Toffees' two recognised strikers - had scored only one league goal combined before the weekend's outing.
And they were failed to add to that poor record on a wet and gloomy evening on Merseyside.
Beto's form was epitomized when he chose to bicycle-kick a golden opportunity from close range, despite having room and time to readjust for a more conventional shot that would have challenged Vicario.
The substitute, as well, was unable to make an impact after replacing the starter in the second half.
It was not for a lack of opportunity. The majority of the home side's attacks came through Grealish and Ndiaye, who tirelessly delivered threatening balls into the Spurs box.
What next for these two sides?
The Toffees: Moyes' men head to Sunderland in the top flight on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs travel to Newcastle's ground on Wednesday, 29 October for their next round League Cup match against Newcastle.